Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis

MyD88, an adaptor molecule downstream of innate pathways, plays a significant tumor-promoting role in sporadic intestinal carcinogenesis of the Apc(min/+) model, which carries a mutation in the Apc gene. Here, we show that deletion of MyD88 in intestinal mesenchymal cells (IMCs) significantly reduce...

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Gepubliceerd in:Cell Rep
Hoofdauteurs: Koliaraki, Vasiliki, Chalkidi, Niki, Henriques, Ana, Tzaferis, Christos, Polykratis, Apostolos, Waisman, Ari, Muller, Werner, Hackam, David J., Pasparakis, Manolis, Kollias, George
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6334226/
https://ncbi.nlm.nih.gov/pubmed/30650348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.12.072
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