Dopamine D(2) receptor occupancy of lumateperone (ITI-007): a Positron Emission Tomography Study in patients with schizophrenia

Dopamine D(2) receptor occupancy (D(2)RO) is a key feature of all currently approved antipsychotic medications. However, antipsychotic efficacy associated with high D(2)RO is often limited by side effects such as motor disturbances and hyperprolactinemia. Lumateperone (ITI-007) is a first-in-class s...

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Gepubliceerd in:Neuropsychopharmacology
Hoofdauteurs: Vanover, Kimberly E., Davis, Robert E., Zhou, Yun, Ye, Weiguo, Brašić, James R., Gapasin, Lorena, Saillard, Jelena, Weingart, Michal, Litman, Robert E., Mates, Sharon, Wong, Dean F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer International Publishing 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333832/
https://ncbi.nlm.nih.gov/pubmed/30449883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-018-0251-1
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