Zolpidem Activation of Alpha 1-Containing GABA(A) Receptors Selectively Inhibits High Frequency Action Potential Firing of Cortical Neurons

Introduction: High frequency neuronal activity in the cerebral cortex can be induced by noxious stimulation during surgery, brain injury or poisoning. In this scenario, it is essential to block cortical hyperactivity to protect the brain against damage, e.g., by using drugs that act as positive allo...

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Publicat a:Front Pharmacol
Autors principals: Neumann, Elena, Rudolph, Uwe, Knutson, Daniel E., Li, Guanguan, Cook, James M., Hentschke, Harald, Antkowiak, Bernd, Drexler, Berthold
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333667/
https://ncbi.nlm.nih.gov/pubmed/30687091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01523
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