CRISPR/Cas9-mediated knockout of CD47 causes hemolytic anemia with splenomegaly in C57BL/6 mice

CD47 (integrin-associated protein), a multi-spanning transmembrane protein expressed in all cells including red blood cells (RBCs) and leukocytes, interacts with signal regulatory protein α (SIRPα) on macrophages and thereby inhibits phagocytosis of RBCs. Recently, we generated a novel C57BL/6J CD47...

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Dettagli Bibliografici
Pubblicato in:Lab Anim Res
Autori principali: Kim, Joo-Il, Park, Jin-Sung, Kwak, Jina, Lim, Hyun-Jin, Ryu, Soo-Kyung, Kwon, Euna, Han, Kang-Min, Nam, Ki-Taek, Lee, Han-Woong, Kang, Byeong-Cheol
Natura: Artigo
Lingua:Inglês
Pubblicazione: Korean Association for Laboratory Animal Science 2018
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333621/
https://ncbi.nlm.nih.gov/pubmed/30671119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5625/lar.2018.34.4.302
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