Exosomal miR-196a derived from cancer-associated fibroblasts confers cisplatin resistance in head and neck cancer through targeting CDKN1B and ING5

BACKGROUND: Cisplatin resistance is a major challenge for advanced head and neck cancer (HNC). Understanding the underlying mechanisms and developing effective strategies against cisplatin resistance are highly desired in the clinic. However, how tumor stroma modulates HNC growth and chemoresistance...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Qin, Xing, Guo, Haiyan, Wang, Xiaoning, Zhu, Xueqin, Yan, Ming, Wang, Xu, Xu, Qin, Shi, Jianbo, Lu, Eryi, Chen, Wantao, Zhang, Jianjun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6332863/
https://ncbi.nlm.nih.gov/pubmed/30642385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1604-0
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