Neuroprotective Effects of Mitochondria-Targeted Plastoquinone and Thymoquinone in a Rat Model of Brain Ischemia/Reperfusion Injury

We explored the neuroprotective properties of natural plant-derived antioxidants plastoquinone and thymoquinone (2-demethylplastoquinone derivative) modified to be specifically accumulated in mitochondria. The modification was performed through chemical conjugation of the quinones with penetrating c...

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Veröffentlicht in:Molecules
Hauptverfasser: Silachev, Denis N., Plotnikov, Egor Y., Zorova, Ljubava D., Pevzner, Irina B., Sumbatyan, Natalia V., Korshunova, Galina A., Gulyaev, Mikhail V., Pirogov, Yury A., Skulachev, Vladimir P., Zorov, Dmitry B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6332348/
https://ncbi.nlm.nih.gov/pubmed/26270657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules200814487
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