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New Polymorphic Forms of Pemetrexed Diacid and Their Use for the Preparation of Pharmaceutically Pure Amorphous and Hemipentahydrate Forms of Pemetrexed Disodium

The preparation of stable amorphous pemetrexed disodium of pharmaceutical purity as well as the process optimization for the preparation of the hemipentahydrate form of pemetrexed disodium are described. Analytical methods for the polymorphic and chemical purity studies of pemetrexed disodium and pe...

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Bibliografski detalji
Izdano u:Molecules
Glavni autori: Michalak, Olga, Łaszcz, Marta, Jatczak, Kamil, Witkowska, Anna, Bujak, Iwona, Groman, Aleksandra, Cybulski, Marcin
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6332103/
https://ncbi.nlm.nih.gov/pubmed/26263958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules200813814
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