An integrated characterization of contractile, electrophysiological, and structural cardiotoxicity of Sophora tonkinensis Gapnep. in human pluripotent stem cell-derived cardiomyocytes

BACKGROUND: Cardiotoxicity remains an important concern in drug discovery and clinical medication. Meanwhile, Sophora tonkinensis Gapnep. (S. tonkinensis) held great value in the clinical application of traditional Chinese medicine, but cardiotoxic effects were reported, with matrine, oxymatrine, cy...

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Vydáno v:Stem Cell Res Ther
Hlavní autoři: Wang, Ruiying, Wang, Min, Wang, Shan, Yang, Ke, Zhou, Ping, Xie, Xueheng, Cheng, Qi, Ye, Jingxue, Sun, Guibo, Sun, Xiaobo
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6330446/
https://ncbi.nlm.nih.gov/pubmed/30635051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-018-1126-4
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