Uncertainty quantification, propagation and characterization by Bayesian analysis combined with global sensitivity analysis applied to dynamical intracellular pathway models

MOTIVATION: Dynamical models describing intracellular phenomena are increasing in size and complexity as more information is obtained from experiments. These models are often over-parameterized with respect to the quantitative data used for parameter estimation, resulting in uncertainty in the indiv...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Bioinformatics
Main Authors: Eriksson, Olivia, Jauhiainen, Alexandra, Maad Sasane, Sara, Kramer, Andrei, Nair, Anu G, Sartorius, Carolina, Hellgren Kotaleski, Jeanette
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Original Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6330009/
https://ncbi.nlm.nih.gov/pubmed/30010712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bty607
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