Dnase1l3 deletion causes aberrations in length and end-motif frequencies in plasma DNA

Circulating DNA in plasma consists of short DNA fragments. The biological processes generating such fragments are not well understood. DNASE1L3 is a secreted DNASE1-like nuclease capable of digesting DNA in chromatin, and its absence causes anti-DNA responses and autoimmunity in humans and mice. We...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Serpas, Lee, Chan, Rebecca W. Y., Jiang, Peiyong, Ni, Meng, Sun, Kun, Rashidfarrokhi, Ali, Soni, Chetna, Sisirak, Vanja, Lee, Wing-Shan, Cheng, Suk Hang, Peng, Wenlei, Chan, K. C. Allen, Chiu, Rossa W. K., Reizis, Boris, Lo, Y. M. Dennis
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2019
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329986/
https://ncbi.nlm.nih.gov/pubmed/30593563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1815031116
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