Heterochromatin suppresses gross chromosomal rearrangements at centromeres by repressing Tfs1/TFIIS-dependent transcription

Heterochromatin, characterized by histone H3 lysine 9 (H3K9) methylation, assembles on repetitive regions including centromeres. Although centromeric heterochromatin is important for correct segregation of chromosomes, its exact role in maintaining centromere integrity remains elusive. Here, we foun...

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Publicat a:Commun Biol
Autors principals: Okita, Akiko K., Zafar, Faria, Su, Jie, Weerasekara, Dayalini, Kajitani, Takuya, Takahashi, Tatsuro S., Kimura, Hiroshi, Murakami, Yota, Masukata, Hisao, Nakagawa, Takuro
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329695/
https://ncbi.nlm.nih.gov/pubmed/30652128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0251-z
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