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Impaired autophagic and mitochondrial functions are partially restored by ERT in Gaucher and Fabry diseases
The major cellular clearance pathway for organelle and unwanted proteins is the autophagy-lysosome pathway (ALP). Lysosomes not only house proteolytic enzymes, but also traffic organelles, sense nutrients, and repair mitochondria. Mitophagy is initiated by damaged mitochondria, which is ultimately d...
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| Udgivet i: | PLoS One |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6329517/ https://ncbi.nlm.nih.gov/pubmed/30633777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0210617 |
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