Analysis of NTRK Alterations in Pan-Cancer Adult and Pediatric Malignancies: Implications for NTRK-Targeted Therapeutics

PURPOSE: Fusions that involve neurotrophic-tropomyosin receptor kinase (NTRK) genes are known drivers of oncogenesis. Therapies that target these ultra-rare, constitutionally active NTRK fusions have been remarkably effective. Herein, we analyze the prevalence of the full array of NTRK alterations—f...

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Pubblicato in:JCO Precis Oncol
Autori principali: Okamura, Ryosuke, Boichard, Amélie, Kato, Shumei, Sicklick, Jason K., Bazhenova, Lyudmila, Kurzrock, Razelle
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2018
Soggetti:
Original Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329466/
https://ncbi.nlm.nih.gov/pubmed/30637364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.18.00183
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