Bioprospecting Reveals Class III ω-Transaminases Converting Bulky Ketones and Environmentally Relevant Polyamines

Amination of bulky ketones, particularly in (R) configuration, is an attractive chemical conversion; however, known ω-transaminases (ω-TAs) show insufficient levels of performance. By applying two screening methods, we discovered 10 amine transaminases from the class III ω-TA family that were 38% to...

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Udgivet i:Appl Environ Microbiol
Main Authors: Coscolín, Cristina, Katzke, Nadine, García-Moyano, Antonio, Navarro-Fernández, José, Almendral, David, Martínez-Martínez, Mónica, Bollinger, Alexander, Bargiela, Rafael, Gertler, Christoph, Chernikova, Tatyana N., Rojo, David, Barbas, Coral, Tran, Hai, Golyshina, Olga V., Koch, Rainhard, Yakimov, Michail M., Bjerga, Gro E. K., Golyshin, Peter N., Jaeger, Karl-Erich, Ferrer, Manuel
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Biotechnology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6328768/
https://ncbi.nlm.nih.gov/pubmed/30413473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02404-18
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