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Antagonistic pleiotropy in mice carrying a CAG repeat expansion in the range causing Huntington’s disease
Antagonist pleiotropy, where a gene exerts a beneficial effect at early stages and a deleterious effect later on in an animal’s life, may explain the evolutionary persistence of devastating genetic diseases such as Huntington’s disease (HD). To date, however, there is little direct experimental evid...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6328633/ https://ncbi.nlm.nih.gov/pubmed/30631090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37102-8 |
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