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Development of a thermostable microneedle patch for polio vaccination

The aim of this study was to develop a dissolving microneedle (MN) patch for administration of inactivated polio vaccine (IPV) with improved thermal stability when compared with conventional liquid IPV. Excipient screening showed that a combination of maltodextrin and D-sorbitol in histidine buffer...

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Bibliographic Details
Published in:Drug Deliv Transl Res
Main Authors: Kolluru, Chandana, Gomaa, Yasmine, Prausnitz, Mark R.
Format: Artigo
Language:Inglês
Published: Springer US 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6328527/
https://ncbi.nlm.nih.gov/pubmed/30542944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13346-018-00608-9
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