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Paricalcitol Inhibits Wnt/β-Catenin Signaling Pathway and Ameliorates Dermal Fibrosis in Bleomycin Induced Scleroderma Model

OBJECTIVES: This study aims to determine the prophylactic and therapeutic efficacy of inhibition of Wnt/β-catenin signaling pathway with paricalcitol in an experimental scleroderma model created with bleomycin (BLM). MATERIALS AND METHODS: Sixty female BALB/c mice (8-week old and weighing 25 g to 30...

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Detalhes bibliográficos
Publicado no:Arch Rheumatol
Main Authors: GÖZEL, Nevzat, DURAN, Fikret, YILDIRIM, Ahmet, YOLBAŞ, Servet, ÖNALAN, Ebru, ÖZERCAN, İbrahim Hanifi, KOCA, Süleyman Serdar
Formato: Artigo
Idioma:Inglês
Publicado em: Turkish League Against Rheumatism 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6328211/
https://ncbi.nlm.nih.gov/pubmed/30632522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5606/ArchRheumatol.2018.6648
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