Targeting Loxosceles spider Sphingomyelinase D with small-molecule inhibitors as a potential therapeutic approach for loxoscelism

Loxosceles spiders’ venoms consist of a mixture of proteins, including the sphingomyelinases D (SMases D), which are the main toxic components responsible for local and systemic effects in human envenomation. Herein, based on the structural information of SMase D from Loxosceles laeta spider venom a...

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Pubblicato in:J Enzyme Inhib Med Chem
Autori principali: Lopes, Priscila Hess, Murakami, Mário T., Portaro, Fernanda C. V., Mesquita Pasqualoto, Kerly Fernanda, van den Berg, Carmen, Tambourgi, Denise V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2019
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6327989/
https://ncbi.nlm.nih.gov/pubmed/30734604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1546698
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