Integrated multi-omics characterization reveals a distinctive metabolic signature and the role of NDUFA4L2 in promoting angiogenesis, chemoresistance, and mitochondrial dysfunction in clear cell renal cell carcinoma

An altered metabolism is involved in the development of clear cell - renal cell carcinoma (ccRCC), and in this tumor many altered genes play a fundamental role in controlling cell metabolic activities. We delineated a large-scale metabolomic profile of human ccRCC, and integrated it with transcripto...

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Detaylı Bibliyografya
Yayımlandı:Aging (Albany NY)
Asıl Yazarlar: Lucarelli, Giuseppe, Rutigliano, Monica, Sallustio, Fabio, Ribatti, Domenico, Giglio, Andrea, Signorile, Martina Lepore, Grossi, Valentina, Sanese, Paola, Napoli, Anna, Maiorano, Eugenio, Bianchi, Cristina, Perego, Roberto A., Ferro, Matteo, Ranieri, Elena, Serino, Grazia, Bell, Lauren N., Ditonno, Pasquale, Simone, Cristiano, Battaglia, Michele
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals 2018
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326659/
https://ncbi.nlm.nih.gov/pubmed/30538212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101685
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