Purification of human butyrylcholinesterase from frozen Cohn fraction IV-4 by ion exchange and Hupresin affinity chromatography

Human butyrylcholinesterase (HuBChE) is being developed as a therapeutic for protection from the toxicity of nerve agents. An enriched source of HuBChE is Cohn fraction IV-4 from pooled human plasma. For the past 40 years, purification of HuBChE has included affinity chromatography on procainamide-S...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Schopfer, Lawrence M., Lockridge, Oksana, David, Emilie, Hinrichs, Steven H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2019
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326467/
https://ncbi.nlm.nih.gov/pubmed/30625168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0209795
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