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A steric gating mechanism dictates the substrate specificity of a Rab-GEF
Correct localization of Rab GTPases in cells is critical for proper function in membrane trafficking, yet the mechanisms that target Rabs to specific subcellular compartments remain controversial. Guanine nucleotide exchange factors (GEFs) activate and consequently stabilize Rab substrates on membra...
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| Publicat a: | Dev Cell |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6324938/ https://ncbi.nlm.nih.gov/pubmed/30528786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2018.11.013 |
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