Hedgehog signaling induces PD-L1 expression and tumor cell proliferation in gastric cancer

Tumor cells expressing programmed cell death ligand 1 (PD-L1) interact with PD-1 on CD8+ cytotoxic T lymphocytes (CTLs) to inhibit CTL effector function. In gastric cancer, the mechanism regulating PD-L1 is unclear. The Hedgehog (Hh) signaling pathway is reactivated in various cancers including gast...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Chakrabarti, Jayati, Holokai, Loryn, Syu, LiJyun, Steele, Nina G., Chang, Julie, Wang, Jiang, Ahmed, Syed, Dlugosz, Andrzej, Zavros, Yana
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6324774/
https://ncbi.nlm.nih.gov/pubmed/30647844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26473
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