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MEK inhibitor enhanced the antitumor effect of oxaliplatin and 5-fluorouracil in MEK1 Q56P-mutant colorectal cancer cells

Mitogen-activated protein kinase kinase (MEK) small molecule inhibitors have been investigated in preclinical or clinical trials for the treatment of cancer. In the present study the genetic test results of 120 patients with colorectal cancer (CRC) were screened and the mutation rate of MEK1 was ide...

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Bibliografski detalji
Izdano u:Mol Med Rep
Glavni autori: Jing, Changwen, Li, Huizi, Du, Yuanyuan, Cao, Haixia, Liu, Siwen, Wang, Zhuo, Ma, Rong, Feng, Jifeng, Wu, Jianzhong
Format: Artigo
Jezik:Inglês
Izdano: D.A. Spandidos 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6323316/
https://ncbi.nlm.nih.gov/pubmed/30535504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2018.9730
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