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In vitro and In vivo Radiosensitization of Glioblastoma Cells by the Poly (ADP-Ribose) Polymerase Inhibitor E7016

PURPOSE: Poly (ADP-ribose) polymerase (PARP) inhibitors are undergoing clinical evaluation for cancer therapy. Because PARP inhibition has been shown to enhance tumor cell sensitivity to radiation, we investigated the in vitro and in vivo effects of the novel PARP inhibitor E7016. EXPERIMENTAL DESIG...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Russo, Andrea L., Kwon, Hyuk-Chan, Burgan, William E., Carter, Donna, Beam, Katie, Weizheng, Xu, Zhang, Jie, Slusher, Barbara S., Chakravarti, Arnab, Tofilon, Philip J., Camphausen, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6322204/
https://ncbi.nlm.nih.gov/pubmed/19147766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-2079
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