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Loss of MeCP2 in immature neurons leads to impaired network integration

Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations or deletions in Methyl-CpG-binding Protein 2 (MeCP2), a brain-enriched transcriptional regulator. MeCP2 is highly expressed during neuronal maturation and its deficiency results in impaired dendritic morphogenesis and reduced d...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Sun, Yi, Gao, Yu, Tidei, Joseph J, Shen, Minjie, Hoang, Johnson T, Wagner, Daniel F, Zhao, Xinyu
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6322069/
https://ncbi.nlm.nih.gov/pubmed/30277526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy338
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