Hepatitis C Virus Downregulates Ubiquitin-Conjugating Enzyme E2S Expression To Prevent Proteasomal Degradation of NS5A, Leading to Host Cells More Sensitive to DNA Damage

Hepatitis C virus (HCV) infection may cause chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. HCV exploits cellular machineries to establish persistent infection. We demonstrate here that ubiquitin-conjugating enzyme E2S (UBE2S), a member of the ubiquitin-conjugating enzyme family (E...

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Vydáno v:J Virol
Hlavní autoři: Pham, Hang T., Nguyen, Tram T. T., Nguyen, Lap P., Han, Sang-Seop, Lim, Yun-Sook, Hwang, Soon B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Virus-Cell Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6321918/
https://ncbi.nlm.nih.gov/pubmed/30381483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01240-18
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