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Brc1 Promotes the Focal Accumulation and SUMO Ligase Activity of Smc5-Smc6 during Replication Stress

As genetic instability drives disease or loss of cell fitness, cellular safeguards have evolved to protect the genome, especially during sensitive cell cycle phases, such as DNA replication. Fission yeast Brc1 has emerged as a key factor in promoting cell survival when replication forks are stalled...

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Bibliografske podrobnosti
izdano v:Mol Cell Biol
Main Authors: Oravcová, Martina, Gadaleta, Mariana C., Nie, Minghua, Reubens, Michael C., Limbo, Oliver, Russell, Paul, Boddy, Michael N.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6321882/
https://ncbi.nlm.nih.gov/pubmed/30348841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00271-18
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