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Factors Affecting Intracellular Delivery and Release of Hydrophilic Versus Hydrophobic Cargo from Mesoporous Silica Nanoparticles on 2D and 3D Cell Cultures

Intracellular drug delivery by mesoporous silica nanoparticles (MSNs) carrying hydrophilic and hydrophobic fluorophores as model drug cargo is demonstrated on 2D cellular and 3D tumor organoid level. Two different MSN designs, chosen on the basis of the characteristics of the loaded cargo, were used...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Pharmaceutics
Main Authors: Desai, Diti, Åkerfelt, Malin, Prabhakar, Neeraj, Toriseva, Mervi, Näreoja, Tuomas, Zhang, Jixi, Nees, Matthias, Rosenholm, Jessica M.
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI 2018
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320991/
https://ncbi.nlm.nih.gov/pubmed/30453596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics10040237
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