Improving Encapsulation of Hydrophilic Chloroquine Diphosphate into Biodegradable Nanoparticles: A Promising Approach against Herpes Virus Simplex-1 Infection

Chloroquine diphosphate (CQ) is a hydrophilic drug with low entrapment efficiency in hydrophobic nanoparticles (NP). Herpes simplex virus type 1 (HSV-1) is an enveloped double-stranded DNA virus worldwide known as a common human pathogen. This study aims to develop chloroquine-loaded poly(lactic aci...

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Publicado en:Pharmaceutics
Autores principales: Lima, Tábata Loíse Cunha, Feitosa, Renata de Carvalho, dos Santos-Silva, Emanuell, dos Santos-Silva, Alaine Maria, Siqueira, Emerson Michell da Silva, Machado, Paula Renata Lima, Cornélio, Alianda Maira, do Egito, Eryvaldo Sócrates Tabosa, Fernandes-Pedrosa, Matheus de Freitas, Farias, Kleber Juvenal Silva, da Silva-Júnior, Arnóbio Antônio
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320969/
https://ncbi.nlm.nih.gov/pubmed/30513856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics10040255
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