Aberrant Epigenetic Regulation in Head and Neck Cancer Due to Distinct EZH2 Overexpression and DNA Hypermethylation

Enhancer of Zeste homologue 2 (EZH2) overexpression is associated with tumor proliferation, metastasis, and poor prognosis. Targeting and inhibition of EZH2 is a potentially effective therapeutic strategy for head and neck squamous cell carcinoma (HNSCC). We analyzed EZH2 mRNA expression in a well-c...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Mochizuki, Daiki, Misawa, Yuki, Kawasaki, Hideya, Imai, Atsushi, Endo, Shiori, Mima, Masato, Yamada, Satoshi, Nakagawa, Takuya, Kanazawa, Takeharu, Misawa, Kiyoshi
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320890/
https://ncbi.nlm.nih.gov/pubmed/30469511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19123707
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