Combining carfilzomib and panobinostat to treat relapsed/refractory multiple myeloma: results of a Multiple Myeloma Research Consortium Phase I Study

Proteasome (PIs) and hystone deacetylase inhibitors (HDACis) have previously shown synergistic activity in the treatment of relapesed/refractory multiple myeloma (RRMM) patients. In this phase 1 study, we combined carfilzomib, a second generation PI, with panobinostat, a HDACi, to determine the maxi...

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Detalhes bibliográficos
Publicado no:Blood Cancer J
Main Authors: Kaufman, Jonathan L., Mina, Roberto, Jakubowiak, Andrzej J., Zimmerman, Todd L., Wolf, Jeffrey J., Lewis, Colleen, Gleason, Charise, Sharp, Cathy, Martin, Thomas, Heffner, Leonard T., Nooka, Ajay K., Harvey, R. Donald, Lonial, Sagar
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320362/
https://ncbi.nlm.nih.gov/pubmed/30610196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41408-018-0154-8
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