Contribution of Adrenal Glands to Intra-tumor Androgens and Growth of Castration Resistant Prostate Cancer.

PURPOSE: Tumor androgens in castration resistant prostate cancer (CRPC) reflect de novo intra-tumoral synthesis or adrenal androgens. We used C.B.−17 SCID mice in which we observed adrenal CYP17A activity to isolate the impact of adrenal steroids on CRPC tumors in vivo. METHODS: We evaluated tumor g...

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Udgivet i:Clin Cancer Res
Main Authors: Mostaghel, Elahe A, Zhang, Ailin, Hernandez, Susana, Mark, Brett T, Zhang, Xiaotun, Tamae, Daniel, Biehl, Heather E, Tretiakova, Maria, Bartlett, Jon, Burns, John, Dumpit, Ruth, Ang, Lisa, Matsumoto, Alvin M, Penning, Trevor M, Balk, Steven P, Morrissey, Colm, Corey, Eva, True, Lawrence D, Nelson, Peter S
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320302/
https://ncbi.nlm.nih.gov/pubmed/30181386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1431
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