A herpesvirus encoded Qa-1 mimic inhibits natural killer cell cytotoxicity through CD94/NKG2A receptor engagement

A recurrent theme in viral immune evasion is the sabotage of MHC-I antigen presentation, which brings virus the concomitant issue of ‘missing-self’ recognition by NK cells that use inhibitory receptors to detect surface MHC-I proteins. Here, we report that rodent herpesvirus Peru (RHVP) encodes a Qa...

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Vydáno v:eLife
Hlavní autoři: Wang, Xiaoli, Piersma, Sytse J, Nelson, Christopher A, Dai, Ya-Nan, Christensen, Ted, Lazear, Eric, Yang, Liping, Sluijter, Marjolein, van Hall, Thorbald, Hansen, Ted H, Yokoyama, Wayne M, Fremont, Daved H
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2018
Témata:
Immunology and Inflammation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320069/
https://ncbi.nlm.nih.gov/pubmed/30575523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38667
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