In vitro anti-inflammatory effects of AZD8999, a novel bifunctional muscarinic acetylcholine receptor antagonist /β2-adrenoceptor agonist (MABA) compound in neutrophils from COPD patients

Recent evidence indicates that AZD8999 (LAS190792), a novel muscarinic acetylcholine receptor antagonist and β2-adrenoceptor agonist (MABA) in development for chronic respiratory diseases, induces potent and sustained relaxant effects in human bronchi by adressing both muscarinic acetylcholine recep...

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Udgivet i:PLoS One
Main Authors: Milara, Javier, Contreras, Sonia, de Diego, Alfredo, Calbet, Marta, Aparici, Mònica, Morcillo, Esteban, Miralpeix, Montserrat, Cortijo, Julio
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6319735/
https://ncbi.nlm.nih.gov/pubmed/30608978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0210188
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