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Structural basis for coupling of protein transport and N-glycosylation at the mammalian endoplasmic reticulum

Protein synthesis, transport and N-glycosylation are coupled at the mammalian endoplasmic reticulum (ER) by complex formation of the ribosome, the Sec61 protein-conducting channel and the oligosaccharyltransferase (OST). Here, we used different cryo-electron microscopy approaches to determine struct...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Braunger, Katharina, Pfeffer, Stefan, Shrimal, Shiteshu, Gilmore, Reid, Berninghausen, Otto, Mandon, Elisabet C., Becker, Thomas, Förster, Friedrich, Beckmann, Roland
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6319373/
https://ncbi.nlm.nih.gov/pubmed/29519914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aar7899
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