The aldose reductase inhibitor epalrestat exerts nephritic protection on diabetic nephropathy in db/db mice through metabolic modulation

Epalrestat is an inhibitor of aldose reductase in the polyol pathway and is used for the management of diabetic neuropathy clinically. Our pilot experiments and accumulated evidences showed that epalrestat inhibited polyol pathway and reduced sorbitol production, and suggested the potential renal pr...

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Publicado en:Acta Pharmacol Sin
Autores principales: He, Jun, Gao, Hao-xue, Yang, Na, Zhu, Xiao-dong, Sun, Run-bin, Xie, Yuan, Zeng, Cai-hong, Zhang, Jing-wei, Wang, Jian-kun, Ding, Fei, Aa, Ji-ye, Wang, Guang-ji
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6318276/
https://ncbi.nlm.nih.gov/pubmed/29930278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-018-0043-5
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