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Stereoselective synthesis of chromane derivatives via a domino reaction catalyzed by modularly designed organocatalysts

A highly enantio- and diastereoselective method for the synthesis of functionalized chroman-2-ones and chromanes was achieved by using an organocatalytic domino Michael/hemiacetalization reaction of aliphatic aldehydes and (E)-2-(2-nitrovinyl)phenols followed by a PCC oxidation and dehydroxylation,...

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Detalles Bibliográficos
Publicado en:Org Biomol Chem
Main Authors: Jakkampudi, Satish, Parella, Ramarao, Zhao, John C.-G.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317902/
https://ncbi.nlm.nih.gov/pubmed/30525178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8ob02677g
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