Cyclin E Overexpression Sensitizes Triple-Negative Breast Cancer to Wee1 Kinase Inhibition

PURPOSE: Poor prognosis in triple-negative breast cancer (TNBC) is due to an aggressive phenotype and lack of biomarker-driven targeted therapies. Overexpression of cyclin E and phosphorylated-CDK2 are correlated with poor survival in TNBC patients, and the absence of CDK2 desensitizes cells to inhi...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Chen, Xian, Low, Kwang-Huei, Alexander, Angela, Jiang, Yufeng, Karakas, Cansu, Hess, Kenneth R., Carey, Jason P. W., Bui, Tuyen N., Vijayaraghavan, Smruthi, Evans, Kurt W., Yi, Min, Ellis, D. Christian, Cheung, Kwok-Leung, Ellis, Ian O., Fu, Siqing, Meric-Bernstam, Funda, Hunt, Kelly K., Keyomarsi, Khandan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317865/
https://ncbi.nlm.nih.gov/pubmed/30181387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1446
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