Hepatitis B virus core protein phosphorylation: Identification of the SRPK1 target sites and impact of their occupancy on RNA binding and capsid structure

Hepatitis B virus (HBV) replicates its 3 kb DNA genome through capsid-internal reverse transcription, initiated by assembly of 120 core protein (HBc) dimers around a complex of viral pregenomic (pg) RNA and polymerase. Following synthesis of relaxed circular (RC) DNA capsids can be enveloped and sec...

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Vydáno v:PLoS Pathog
Hlavní autoři: Heger-Stevic, Julia, Zimmermann, Peter, Lecoq, Lauriane, Böttcher, Bettina, Nassal, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317823/
https://ncbi.nlm.nih.gov/pubmed/30566530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007488
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