IgA tetramerization improves target breadth but not peak potency of functionality of anti-influenza virus broadly neutralizing antibody

Mucosal immunoglobulins comprise mainly secretory IgA antibodies (SIgAs), which are the major contributor to pathogen-specific immune responses in mucosal tissues. These SIgAs are highly heterogeneous in terms of their quaternary structure. A recent report shows that the polymerization status of SIg...

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Pubblicato in:PLoS Pathog
Autori principali: Saito, Shinji, Sano, Kaori, Suzuki, Tadaki, Ainai, Akira, Taga, Yuki, Ueno, Tomonori, Tabata, Koshiro, Saito, Kumpei, Wada, Yuji, Ohara, Yuki, Takeyama, Haruko, Odagiri, Takato, Kageyama, Tsutomu, Ogawa-Goto, Kiyoko, Multihartina, Pretty, Setiawaty, Vivi, Pangesti, Krisna Nur Andriana, Hasegawa, Hideki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317788/
https://ncbi.nlm.nih.gov/pubmed/30605488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007427
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