The Ashitaba (Angelica keiskei) chalcones 4-hydroxyderricin and xanthoangelol suppress melanomagenesis by targeting BRAF and PI3-K

Malignant melanoma is an aggressive tumor of the skin and still lacks effective preventive and therapeutic treatments. In melanoma, both the BRAF/MEK/ERK and PI3-K/AKT signaling pathways are constitutively activated through multiple mechanisms, which result in cell cycle progression and prevention o...

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Detalhes bibliográficos
Publicado no:Cancer Prev Res (Phila)
Main Authors: Zhang, Tianshun, Wang, Qiushi, Fredimoses, Mangaladoss, Gao, Ge, Wang, Keke, Chen, Hanyong, Wang, Ting, Oi, Naomi, Zykova, Tatyana A., Reddy, Kanamata, Yao, Ke, Ma, Weiya, Chang, Xiaoyu, Lee, Mee-Hyun, Rathore, Moeez Ghani, Bode, Ann M., Ashida, Hitoshi, Dong, Zigang
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317334/
https://ncbi.nlm.nih.gov/pubmed/29980517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-18-0092
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