STAT3 enhances the constitutive activity of AGC kinases in melanoma by transactivating PDK1

BACKGROUND: The PI3K/Akt and the STAT3 pathways are functionally associated in many tumor types. Both in vitro and in vivo studies have revealed that either biochemical or genetic manipulation of the STAT3 pathway activity induce changes in the same direction in Akt activity. However, the implicated...

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Publicado en:Cell Biosci
Autores principales: Picco, María Elisa, Castro, María Victoria, Quezada, María Josefina, Barbero, Gastón, Villanueva, María Belén, Fernández, Natalia Brenda, Kim, Hyungsoo, Lopez-Bergami, Pablo
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317239/
https://ncbi.nlm.nih.gov/pubmed/30622697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-018-0265-8
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