Synthesis and Antiproliferative Activity of Marine Bromotyrosine Purpurealidin I and Its Derivatives

The first total synthesis of the marine bromotyrosine purpurealidin I (1) using trifluoroacetoxy protection group and its dimethylated analog (29) is reported along with 16 simplified bromotyrosine derivatives lacking the tyramine moiety. Their cytotoxicity was evaluated against the human malignant...

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Udgivet i:Mar Drugs
Main Authors: Bhat, Chinmay, Ilina, Polina, Tilli, Irene, Voráčová, Manuela, Bruun, Tanja, Barba, Victoria, Hribernik, Nives, Lillsunde, Katja-Emilia, Mäki-Lohiluoma, Eero, Rüffer, Tobias, Lang, Heinrich, Yli-Kauhaluoma, Jari, Kiuru, Paula, Tammela, Päivi
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6316490/
https://ncbi.nlm.nih.gov/pubmed/30513862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md16120481
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