Oncogenic Activation of Nrf2, Though as a Master Antioxidant Transcription Factor, Liberated by Specific Knockout of the Full-Length Nrf1α that Acts as a Dominant Tumor Repressor

Liver-specific knockout of Nrf1 in the mouse leads to spontaneous development of non- alcoholic steatohepatitis with dyslipidemia, and then its deterioration results in hepatoma, but the underlying mechanism remains elusive to date. A similar pathological model is reconstructed here by using human N...

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Bibliographic Details
Published in:Cancers (Basel)
Main Authors: Qiu, Lu, Wang, Meng, Hu, Shaofan, Ru, Xufang, Ren, Yonggang, Zhang, Zhengwen, Yu, Siwang, Zhang, Yiguo
Format: Artigo
Language:Inglês
Published: MDPI 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6315801/
https://ncbi.nlm.nih.gov/pubmed/30562963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers10120520
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