Administration of Enalapril Started Late in Life Attenuates Hypertrophy and Oxidative Stress Burden, Increases Mitochondrial Mass, and Modulates Mitochondrial Quality Control Signaling in the Rat Heart

Mitochondrial dysfunction is a relevant mechanism in cardiac aging. Here, we investigated the effects of late-life enalapril administration at a non-antihypertensive dose on mitochondrial genomic stability, oxidative damage, and mitochondrial quality control (MQC) signaling in the hearts of aged rat...

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Veröffentlicht in:Biomolecules
Hauptverfasser: Picca, Anna, Sirago, Giuseppe, Pesce, Vito, Lezza, Angela Maria Serena, Calvani, Riccardo, Bossola, Maurizio, Villani, Emanuele Rocco, Landi, Francesco, Leeuwenburgh, Christiaan, Bernabei, Roberto, Carter, Christy S., Marzetti, Emanuele
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6315620/
https://ncbi.nlm.nih.gov/pubmed/30563025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom8040177
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