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VEGF expands erythropoiesis via hypoxia-independent induction of erythropoietin in noncanonical perivascular stromal cells

Insufficient erythropoiesis due to increased demand is usually met by hypoxia-driven up-regulation of erythropoietin (Epo). Here, we uncovered vascular endothelial growth factor (VEGF) as a novel inducer of Epo capable of increasing circulating Epo under normoxic, nonanemic conditions in a previousl...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Greenwald, Alissa C., Licht, Tamar, Kumar, Saran, Oladipupo, Sunday S., Iyer, Seema, Grunewald, Myriam, Keshet, Eli
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314526/
https://ncbi.nlm.nih.gov/pubmed/30545903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180752
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