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A single AT-GC exchange can modulate charge transfer-induced p53-DNA dissociation
Using molecular dynamics simulations and electronic structure theory, we shed light on the charge dynamics that causes the differential interaction of tumor suppressor protein p53 with the p21 and Gadd45 genes in response to oxidative stress. We show that the sequence dependence of this selectivity...
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| 出版年: | Chem Commun (Camb) |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6314182/ https://ncbi.nlm.nih.gov/pubmed/30520908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cc09048c |
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