Oxaloacetic acid mediates ADP-dependent inhibition of mitochondrial complex II–driven respiration

We recently reported a previously unrecognized mitochondrial respiratory phenomenon. When [ADP] was held constant (“clamped”) at sequentially increasing concentrations in succinate-energized muscle mitochondria in the absence of rotenone (commonly used to block complex I), we observed a biphasic, in...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Fink, Brian D., Bai, Fan, Yu, Liping, Sheldon, Ryan D., Sharma, Arpit, Taylor, Eric B., Sivitz, William I.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2018
Ämnen:
Bioenergetics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314144/
https://ncbi.nlm.nih.gov/pubmed/30385511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005144
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