Modeling and Simulation of hGAT1: A Mechanistic Investigation of the GABA Transport Process

Human γ-Aminobutyric acid transporter 1 (hGAT1) is a Na(+)/Cl(−) dependent co-transporter that plays a key role in the inhibitory neurotransmission of GABA in the brain. Due to the lack of structural data, the exact co-transport mechanism of GABA reuptake by hGAT1 remains unclear. To examine the rol...

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Bibliografiske detaljer
Udgivet i:Comput Struct Biotechnol J
Main Authors: Zafar, Sadia, Nguyen, Megin E., Muthyala, Ramaiah, Jabeen, Ishrat, Sham, Yuk Y.
Format: Artigo
Sprog:Inglês
Udgivet: Research Network of Computational and Structural Biotechnology 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6312766/
https://ncbi.nlm.nih.gov/pubmed/30619541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2018.12.003
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