Zonisamide Enhances Motor Effects of Levodopa, Not of Apomorphine, in a Rat Model of Parkinson's Disease

Zonisamide is a relatively recent drug for Parkinson's disease. Multiple hypotheses have been proposed to explain the antiparkinsonian effects of zonisamide. However, it is still unclear whether the effect of zonisamide is mainly due to dopaminergic modification in the striatum, or if zonisamid...

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Bibliographic Details
Published in:Parkinsons Dis
Main Authors: Nishijima, Haruo, Miki, Yasuo, Ueno, Shinya, Tomiyama, Masahiko
Format: Artigo
Language:Inglês
Published: Hindawi 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6312621/
https://ncbi.nlm.nih.gov/pubmed/30662707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/8626783
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